APCDD1 was noted because: (i) its super-enhancer intensity ranked No.2 in SKNMC cells (Figure 3A); (ii) it was specifically upregulated in EWS cells (Figure 4C) and (iii) it has been identified as a tumor-promoting factor in colon cancer (34). The gene discussed is EWSR1; the disease is malignant colon neoplasm.