TP53 and adenocarcinoma: Genetically engineered mouse models that express Trp53 R172H or R270H mutations (corresponding to the human TP53 R175H or R273H, respectively) developed spontaneous adenocarcinomas in the intestine and lung with the nuclear accumulation of p53, findings not noted in Trp53Null (deleted) mutant mice (Lang et al., 2004; Olive et al., 2004).