A mouse model study using ‘sleeping beauty’ transposon also indicated that the mutation of Arid1a, a component of SWI/SNF, was enriched by transposons in in vivo intestinal tumors when the mouse carried heterozygous Trp53 R172H (human R175H) mutation, suggesting an additive effect of mutations in p53 and the SWI/SNF complex for intestinal tumorigenesis (Takeda et al., 2015). This evidence concerns the gene SMARCA1 and intestinal neoplasm.