APC and colorectal cancer: In non-hypermutated colorectal cancers, the mutation rate of TP53 is about 55%–60%, which is the second-most frequent mutation observed in colorectal cancer (APC mutation is found >80%), whereas the mutation rate of TP53 is significantly decreased to ~20% in hypermutated colorectal cancers (The Cancer Genome Atlas Network, 2012; Kandoth et al., 2013; Giannakis et al., 2016).