Recent genome-wide analyses have identified frequently mutated genes in human colorectal cancers, including APC, KRAS, SMAD4, and TP53, mutations of which are found in about 10–80% of non-hypermutated colorectal cancers (The Cancer Genome Atlas Network, 2012; Giannakis et al., 2016). This evidence concerns the gene SMAD4 and colorectal cancer.