TMEM106B and frontotemporal dementia: Remarkably, these data show that mutant CHMP2B has the opposite effect in dendrites to those caused by reduced levels of the FTD risk factor TMEM106B, which has been found to increase the transport of dendritic lysosomes and to also decrease dendritic branching (Schwenk et al., 2014; Stagi et al., 2014).