Further to this, TMEM106B, a risk factor for FTD (Van Deerlin et al., 2010; van der Zee and Van Broeckhoven, 2011), is located at the endolysosome and directly affects endolysosomal function, including dendritic endolysosomal trafficking (Brady et al., 2013; Schwenk et al., 2014; Stagi et al., 2014; Klein et al., 2017). Here, TMEM106B is linked to frontotemporal dementia.