TMEM106B and frontotemporal dementia: Finally, TMEM106B, the most well recognized risk factor for FTD (Van Deerlin et al., 2010; Finch et al., 2011; van der Zee and Van Broeckhoven, 2011; Gallagher et al., 2014; van Blitterswijk et al., 2014), is localized to late endosomes and lysosomes (Chen-Plotkin et al., 2012; Lang et al., 2012; Brady et al., 2013).