With complementary experimental approaches, we have demonstrated that moderate inhibition of JNK signaling in the A. stephensi midgut extends lifespan and enhances resistance to the human malaria parasite P. falciparum. Resistance was independent of effects on NF-κB-dependent innate immunity, adding to the list of similar observations in A. stephensi that highlight the importance of alternative signaling pathways and intermediary metabolism in mediating anti-parasite resistance [14, 20, 22]. This evidence concerns the gene MAPK8 and malaria.