By that view, pharmacological D2 agonist stimulations that promote reward seeking, such as D2/D3 agonist medication induction of addictive-like motivations in Parkinson’s patients with Dopamine Dysregulation Syndrome [52], would be seen as inducing neuronal inhibitions of D2 neurons via inhibitory Gi G-protein receptor mechanisms. Here, GNAI1 is linked to Parkinsonism.