Taken together, these results show that the CXCR4 chemokine receptor is expressed by splenic cDCs, present in all three cDC subsets, and that the maturation state and CXCR4 expression within splenocytes from FLT-3 ligand-secreting tumor mice are comparable to naïve mice. The gene discussed is CXCR4; the disease is neoplasm.