Whereas the CXCR4/CXCL12 pathway in DC homing to the cornea has not been directly investigated, Cook et al.61 found elevated corneal CXCR4 gene expression in parallel to CCR1, 2, and 5, 3 days after infection when examining the expression profile of chemokines (including CCL3/4, RANTES, and monocyte chemoattractant protein-1 [MCP]-1), as well as chemokine receptors (including CCR1-7 and CXCR4) in a murine model of herpes simplex virus (HSV)-1 infection. Here, CCL5 is linked to infection.