Although hepatocyte may not secrete PANDER, an increase in hepatic PANDER expression will trigger gluconeogenesis to cause hyperglycemia, which stimulates PANDER expression and secretion from pancreatic β cells.4, 20 An increase in circulating PANDER levels will in return exaggerate insulin resistance and induce PANDER expression in hepatocytes. This evidence concerns the gene FAM3B and Hyperglycemia.