A putative secretory isoform of PANDER had been reported to be detected in the medium of cultured hepatocytes after PANDER overexpression,14 while the secretory PANDER isoform failed to be detected in mouse livers and cultured hepatocytes in several other studies.13, 21, 22 Moreover, a non‐secretory PANDER isoform has been reported to promote invasion and metastasis of human colon cancer cells.23 Collectively, these findings had raised an important hypothesis that PANDER may modulate glucose and lipid metabolism via non‐secretory mechanism in hepatocytes. The gene discussed is FAM3B; the disease is colonic neoplasm.