In contrast, starting at 6 months of age, there was a significant age‐dependent increase in microglia activation in the medial hippocampus of 3xTg‐AD mice compared to age‐matched NonTg mice (p < 0.0001 for fluorescent intensity and p < 0.01 for number of Iba1‐positive cells; Figure 5b–e). Here, AIF1 is linked to Alzheimer disease.