These mice develop Aβ and tau pathology, as well as neuroinflammation and cognitive deficits (Billings, Oddo, Green, McGaugh, & LaFerla, 2005; Kitazawa, Oddo, Yamasaki, Green, & LaFerla, 2005; Oddo, Caccamo, et al., 2006; Oddo, Caccamo, Kitazawa, et al., 2003; Oddo, Caccamo, Shepherd, et al., 2003; Oddo, Vasilevko, et al., 2006). The gene discussed is MAPT; the disease is Cognitive impairment.