APP and Cognitive impairment: Moreover, overexpression of DISC1, but not mutant DISC1, which harbors a mutated LIR motif and fails to induce mitophagy, via AAV8 in the hippocampus of 8‐month‐old APP/PS1 transgenic mice, rescues mitochondrial dysfunction and cognitive deficits, which is concomitant with attenuated synaptic loss and Aβ accumulation in the brains of these transgenic mice.