To examine whether overexpression of DISC1 ameliorates cognitive deficits through enhancing mitophagy, we injected bilaterally AAV8 encoding either DISC1, muFSFI, or GFP into the hippocampus of 8‐month‐old APP/PS1 transgenic mice and performed behavioral tests 4 months after injection. Here, DISC1 is linked to Cognitive impairment.