TNF and metabolic disease: In fact, pro‐inflammatory genes as TNF‐ɑ, IL‐1ɑ, IL‐1β, and NLRP3 are associated with a wide range of age‐related disorders, including cardiovascular, neurodegenerative, and metabolic diseases (Anders, 2016; Croft et al., 2012; Ozaki et al., 2015) and the level of soluble TNF‐ɑ R1 was identified as a predictor of 10‐year all‐causes of mortality (Varadhan et al., 2014).