Complex interplay between the ARF protein encoded by the INK4A‐ARF locus, the p53 tumor suppressor, and the histone demethylase Jumonji D3 may also occur as this has been reported in mouse neural stem cells (Sola et al., 2011), HEK293 cells, and glioblastoma cells (Ene et al., 2012). This evidence concerns the gene CDKN2A and glioblastoma.