In the Center for Neurodegenerative Disease Research (CNDR) Brain Bank at the University of Pennsylvania, only 35% of 247 autopsy-confirmed AD brains examined for the presence of tau, Aβ, α-synuclein, and TDP-43 deposits had only plaques and tangles as the underlying cause of dementia, while 22% had all four of these pathologies [300]. Here, TARDBP is linked to Alzheimer disease.