CSF α-synuclein shows a strong correlation with CSF t-tau and a weaker correlation with p-tau in AD, but a subset of patients in the ADNI cohort had a mismatch—high p-tau accompanied by low α-synuclein levels—it was hypothesized that this CSF signature could represent concomitant LB pathology in AD patients [366]. The gene discussed is MAPT; the disease is Alzheimer disease.