Overall, the available data indicate that CSF neurogranin (and potentially, plasma neuronally derived exosomes) could be useful as an AD biomarker for subject/patient selection and prognosis (Tables 1 and 2), although results may vary depending on the neurogranin fragment being measured (full-length vs C-terminal peptides and C-terminus intact vs truncated). The gene discussed is NRGN; the disease is Alzheimer disease.