Piribedil specifically induces MLL-rearranged leukemia cell cycle arrest, growth inhibition, myeloid differentiation and apoptosis with little toxicity to non-MLL-rearranged cells, and sensitizes MLL-rearranged leukemia cells to doxorubicin-induced apoptosis (Table 2) (65). This evidence concerns the gene KMT2A and leukemia.