WDR5 and neoplasm: Mechanistically, WDR5 up-regulates cyclin B1, cyclin E1, cyclin E2, UHMK1, MCL1, BIRC3, and Nanog gene transcription through inducing histone H3K4 trimethylation, resulting in bladder cancer cell proliferation, self-renewal and chemo-resistance to cisplatin in vitro and tumor growth in vivo (58).