Suppressing proliferation and inducing differentiation in C/EBPα p30 mutant acute myeloid leukemia cells, and blocking WDR5-N-Myc/c-Myc protein complex formation, Myc target gene expression and neuroblastoma and pancreatic ductal adenocarcinoma cell proliferation. The gene discussed is CEBPA; the disease is pancreatic ductal adenocarcinoma.