WDR5 binds c-Myc and N-Myc proteins via their MYC box IIIb motif, and the interaction is essential for histone H3K4 trimethylation at Myc-responsive element E-Boxes of Myc target gene promotes, Myc target gene transcription and Myc-induced cancers, such as breast cancer and neuroblastoma (Figure 1C) (34, 35). The gene discussed is MYCN; the disease is cancer.