GHRL and Insulin resistance: Evidence from clinical studies suggested that serum ghrelin correlated negatively with body mass index (BMI), waist circumference, insulin resistance (IR), and metabolic syndrome (MS), which indicated that ghrelin may be involved in the occurrence of T2DM (Serra-Prat et al., 2009; Amini et al., 2012; Soriano-Guillen et al., 2016).