KEAP1: Oxidative stress → proliferation and survival in HCCHGF: Overexpressed HGF binds with c-Met proliferation & survival in HCC through c-MET signaling pathway CDKN2A: G1/S cell cycle ESR1: Estrogen signaling pathway → proliferationTP53, CDKN2A, ATR, ATM: p53 signaling pathway, replicative senescence, cell cycle. The gene discussed is KEAP1; the disease is hepatocellular carcinoma.