On the contrary the observation that the percentage of NK cells expressing CD107a in TKI-treated CML old patients was lower than in healthy elderly donors, together with the lower expression of NK receptors in old TKI-treated CML patients compared with healthy elderly healthy donors (Figure 6C), support that the alterations on NK cells observed in healthy elderly donors likely associated with chronic virus infection, such as CMV, and inflamm-aging are not observed in old TKI-treated CML patients. This evidence concerns the gene LAMP1 and viral infectious disease.