GALR1 and progressive pseudorheumatoid arthropathy of childhood: In the present study, lower level of 5-HT in PPD model rats and ameliorated depression-like behavior together with reversed 5-HT level after GALR1-siRNA treatment suggesting that antidepressant effect of GALR1-siRNA might be mediated by reversing downregulation of 5-HT in PFC.