The protective effects of the latter studies are centered on a neutrophil response, both in terms of neutrophils being the major source of LXA4 production during ischemia and that ALX/FPR2 signaling limits the neutrophil adherence and infiltration into the ischemic area (Brancaleone et al., 2013; Vital et al., 2016). Here, FPR2 is linked to ischemia.