Opposite to the strong microglial activation in amyloidogenic mice, we have recently demonstrated a significant microglial degenerative process in the hippocampus of AD patients (Sanchez-Mejias et al., 2016; Gutierrez and Vitorica, 2018; Navarro et al., 2018), a brain region with a more prominent tau pathology than Abeta accumulation. The gene discussed is APP; the disease is Alzheimer disease.