In agreement with our results, a robust neuroinflammatory response characterized by microgliosis has been described in the mouse model expressing human P301S mutated tau protein under the control of the Thy1 promotor (Bellucci et al., 2004) and in patients with frontotemporal dementia carrying the P301S mutation (Bellucci et al., 2011). Here, MAPT is linked to frontotemporal dementia.