In fact, aggregated phospho-tau (Sarkosyl-resistant fraction) extracted from either P301S model (showing a 96.8 ± 0.43% of BV2 viable cells after 12 h of treatment with Sarkosyl-resistant fraction, n = 3) or even from AD patients (Sanchez-Mejias et al., 2016) produced no microglial toxicity. Here, MAPT is linked to Alzheimer disease.