In fact, microglial activation has been linked to tau deposition in different human tauopathies, such as AD (Sheffield et al., 2000), progressive supranuclear palsy (Ishizawa and Dickson, 2001) and corticobasal degeneration (Gerhard et al., 2004; Henkel et al., 2004), as well as in transgenic rats expressing human non-mutated truncated tau (Zilka et al., 2009; Stozicka et al., 2010), and in different transgenic mice with overexpression of the human mutated tau protein. This evidence concerns the gene MAPT and Classical progressive supranuclear palsy.