SHBG and Hepatic fibrosis: In contrast, circulating SHBG levels were increased in proportion to the severity of hepatic fibrosis (F1, 84.0 ± 33.3 nmol/L; F2, 94.5 ± 51.6 nmol/L; F3, 153.2 ± 87.4 nmol/L; F4, 168.3 ± 42.1 nmol/L; Fig. 2b).