NFKBIA and inflammatory bowel disease: Subsequently, ubiquitination of IκBα is induced and ubiquitinated IκBα is degraded by proteasome, leading to translocation of NF-κB into the nucleus.(9–11) NF-κB has various physiological functions to maintain homeostasis of the body, and its abnormal control plays a crucial role in various inflammatory disorders and malignant diseases.(10,11) In IBD, activation of NF-κB is enhanced, and along with this, excessive expression of inflammatory cytokines such as IL-1β, TNFα and IL-6 in the mucosa has been reported.(12,13)