In our previous work26 we showed that GR activation in astrocytes leads to upregulation of two protein kinases known to regulate metabolism, namely the pyruvate dehydrogenase kinase-4 (PDK4) that controls entering of glucose into the citric acid cycle and serum and glucocorticoid-regulated kinase-1 (SGK1), a protein associated with PTSD and depression31. The gene discussed is PDK4; the disease is post-traumatic stress disorder.