Strikingly, blockade of IFNAR signaling after the first week of infection resulted in approximately a 60% increase in the proportion of IL-10-producing Tfh cells (Fig. 6f, g and Supplementary Figure 7H, I) which was further associated with a 25% increase in the proportion of GC B cells on day 21 p.i. (Supplementary Figure 7J). The gene discussed is IFNAR1; the disease is infection.