Furthermore, SIRT1 small interfering RNA (siRNA) had effects on p-P65, TNF-α, IL-1β, and IL-6 genes similar to the effects induced by miR-141 (Fig. 5b), indicating that miR-141 regulates IDD progression by targeting the SIRT1/NF-κB pathway. Here, TNF is linked to intervertebral disk degenerative disorder.