AKT1 and colorectal neoplasm: Lycopene inhibits the cellular growth of HT-29 cells in a dose-dependent manner by effectively inhibiting the phosphorylation of Protein kinase B (Akt) and therefore silencing Phosphatidylinositol-4,5-bisphosphate 3-kinase (PIK3)/Akt, a signaling pathway that is associated with colorectal tumor development [126].