Association between water-soluble polysacharide (glucomannan) and prebiotics (inulin), before initiation of CRC with azoxymethane (AOM) in a mouse model up-regulated gene expression of antioxidant enzymes, such as glutathione peroxidase 2 (GPX2), glutathione-S-transferase (GST) and catalase (CAT) and increased short fatty acid chain fatty acids production [195]. The gene discussed is GPX2; the disease is colorectal carcinoma.