NOTCH1 and neoplasm: Several mechanisms are involved: Inhibition of tumor growth, modulation of several pathways (Wnt/β catenin, PI3K/Akt, Notch-1), anti-inflammatory activity, up-regulation of antioxidant enzymes and NRf2 expression, down-regulation of microbial enzymes activity, activation of caspases or increased Bax/Bcl-2 ratio.