To gain insights into the mechanistic implications of NSCLC response to Ezh2 inhibition in vivo, we next investigated whether GSK126-regulated genes involve direct PRC2 targets by interrogating a chromatin immunoprecipitation sequencing (ChIP-seq) profile of H3K27me3 previously generated in KrasG12D/+;Trp53−/− orthotopic lung tumors (Serresi et al., 2016). This evidence concerns the gene TP53 and non-small cell lung carcinoma.