Several mechanisms have been shown to downregulate or inactivate type I IFN responses in cancer cells, including IFN signaling inhibition by MEK/extracellular signal-regulated kinase (ERK) signaling (72) or epigenetic silencing of the IFN-responsive transcription factor interferon regulatory factor 7 (IRF7) or IRF5 (73). Here, IRF5 is linked to cancer.