Increased expression of SIKE mRNA was significantly correlated with worse OS for all gastric cancer, HR = 1.71 (1.44–2.04), P=9e-10 (Figure 5A) similarly poor OS was noted in intestinal type, HR = 1.59 (1.14–2.23), P=0.0062 (Figure 5B). Here, SIKE1 is linked to gastric cancer.