E2F1 and gastric cancer: The Lauren classification subtype results revealed that increased E2F1 mRNA expression was correlated with unfavourable OS for patients with intestinal GC, HR = 2.56 (1.84–3.58), P=1 × 10−8 (Figure 1B) and patients with diffuse GC, HR = 1.68 (1.18–2.4), P=0.0036 (Figure 1C).