E2F3 mRNA expression was significantly associated with poor OS for all GC patients and intestinal cancer patients, HR = 1.88 (1.57–2.26), P=4.2 × 10−12 (Figure 3A), HR = 2.34 (1.7–3.21), P=7.4 × 10−8 (Figure 3B) respectively. The gene discussed is E2F3; the disease is gastric cancer.