It is speculated that this difference in induction is dependent on the EBV gene responsible for the induction; MYC is induced by EBNA2 (24), which is abundantly expressed immediately after de novo infection, and ICAM1 expression is mediated through NF-κB activation by LMP1 (23), which is less abundant for several days after infection in primary B cells (35). The gene discussed is ICAM1; the disease is infection.