BRCA1 and cancer: These include heterozygotes for likely pathogenic and pathogenic variants in the highly penetrant cancer risk genes BRCA1 (MIM:113705), which is associated with hereditary breast and ovarian cancer (MIM: 604370), and SDHB (MIM: 185470), which is associated with hereditary paraganglioma and pheochromoctytoma (MIMs: 115310, 171300).