The risk allele—in the APC gene (MIM: 611731)—is a well-studied founder variant in the Ashkenazi Jewish population that the NCCN has described as a moderate risk allele for colon cancer and for which it has issued screening guidelines for individuals who are heterozygous for this variant (Boursi et al. 2013; Liang et al. 2013; National Comprehensive Cancer Network 2016). The gene discussed is APC; the disease is colonic neoplasm.