These variants were primarily in genes associated with autosomal dominant disease, although one pathogenic variant was in MUTYH (MIM: 604933)—a gene which is associated with autosomal recessive MUTYH-associated polyposis (MIM: 608456)—but for which heterozygotes are known to be at increased lifetime colon cancer risk (5.6% for female heterozygotes and 7.2% for male heterozygotes by age 70; higher for patients with a first-degree relative with colon cancer) (Win et al. 2014). This evidence concerns the gene MUTYH and autosomal dominant disease.