EZH2 and neoplasm: Our results identified a feedback loop of miR-6868-5p/FOXM1, in which miR-6868-5p inhibits tumor angiogenesis by suppressing FOXM1-IL-8 axis, and in turn FOXM1 downregulates miR-6868-5p by stimulating EZH2-mediated transcriptional suppression of miR-6868-5p (Fig. 8d).