CXCR2 and neoplasm: No conserved miR-6868-5p binding sites were identified in the 3’-UTR region of IL-8, excluding that IL-8 was directly targeted by miR-6868-5p, IL-8, also known as CXCL8, has been well documented to promote tumor angiogenesis mainly by binding to its receptor CXCR2 [32–34].