The levels of TGs (1.15 ± 0.71 mmol/L), TC (5.00 ± 1.48 mmol/L), HDL-C (1.16 ± 1.03 mmol/L), LDL-C (3.19 ± 1.27 mmol/L), ApoA-1 (1.10 ± 0.24 g/L), and Apo-B (0.88 ± 0.29 g/L) in HCC patients were significantly lower than those in the control group, which was age- and sex-matched (TG: 1.53 ± 0.71 mmol/L, TC: 5.22 ± 0.97 mmol/L, HDL-C: 1.32 ± 0.35 mmol/L, LDL-C: 3.48 ± 0.88 mmol/L, ApoA-1: 1.42 ± 0.22 g/L, Apo-B: 1.07 ± 0.25 g/L). This evidence concerns the gene APOB and hepatocellular carcinoma.