Firstly, ApoA-1 negatively influences the tumour microenvironment in terms of decreased overall metastasis and an increased accumulation of tumour-associated macrophages (TAMs) with an M1-like antitumour phenotype in direct contrast with the traditional anti-inflammatory and immunosuppressive functions [25]; ApoA-1 may also increase the level of tumour cell killing macrophages and may increase the recruitment of CD8 T cells and decrease the levels of the anti-apoptotic protein survivin within the tumour bed. This evidence concerns the gene CD8A and neoplasm.