miR-148a and miR-21-5p were previously observed as differentially expressed in T1D serum/plasma; in the present study such differential expression is confirmed and additionally associated to bone fragility and bone metabolism alterations in T1D, being inversely correlated with BMD-TB (miR-148a) and BMC-FEM (miR-21-5p) and positively associated with PTH levels (miR-148a). The gene discussed is PTH; the disease is type 1 diabetes mellitus.