A promising strategy to induce apoptosis in glioma cells by the extrinsic pathway, with a possible amplification of the intrinsic pathway, involves reactivating the signaling pathway TRAIL/TRAILR, which induces the formation of DISC and the ensuing activation of apoptosis initiator and effector caspases, with a low toxicity at the peripheral and cerebral levels. This evidence concerns the gene TNFSF10 and central nervous system cancer.