It has been suggested that low levels of caspase-8 and FADD are related to apoptosis resistance via death inducers by TRAIL in glioma [71], since expression levels of the receptors TRAIL-R1 and TRAIL-R2 are increased in biopsy samples from astrocytoma and glioblastoma patients [71]. This evidence concerns the gene TNFSF10 and central nervous system cancer.