Sunitinib decreased the length and density of blood vessels, showing anti-invasive and pro-apoptotic effects due to a partially inhibited phosphorylation of Src at Tyr-418 and FAK at Tyr-397, along with an inhibited activation of caspase-3, in U87MG and GL15 glioma cells and in intracerebral models of GBM [240]. This evidence concerns the gene CASP3 and central nervous system cancer.