On the other hand, Chang et al. showed that at doses lower than 20 μM gefitinib inhibits cell growth and colony formation in U87 and T96G glioma cells, by activating the LKB1/AMPK pathway and inducing autophagy (autophagosome accumulation, LC3-II, and p62 degradation) [216]. Here, STK11 is linked to central nervous system cancer.