SQSTM1 and central nervous system cancer: Hu et al. reported increased levels of the BNIP3 protein in U87 and T96G glioma cell lines under hypoxic conditions, inducing autophagy and promoting cell survival, and that the conversion of LC3-I into LC3-II, the degradation of p62, and the expression of BNIP3 were decreased by inhibitors of HIF-1α, promoting cell death by apoptosis [140].