Furthermore, it has been proved that higher-grade gliomas show lower expression of autophagy-related proteins with respect to lower-grade gliomas [117]: Shukla et al. reported that a lower ULK1/2 expression due to p53 methylation (inactivation) in gliomas favors astrocytic transformation by inhibiting autophagy [118]. Here, ULK1 is linked to central nervous system cancer.