On the other hand, the use of inhibitors of the HSF-1/HSP90/BAG3 pathway increases the antineoplastic effect of AT101, reactivating caspase-dependent apoptosis in the U252 and U343 glioma cell lines through a downregulation of Bcl-2 and Mcl-1 and an increase of Bax and mitochondrial dysfunction [310]. The gene discussed is BAG3; the disease is central nervous system cancer.