Treatment of glioma cells with ATB-737 and TRAIL has proved to be effective to induce apoptosis by cleaving Bid into tBid, activating caspase-8, and facilitating the accumulation of tBid on the mitochondrial membrane after ABT-737 neutralized Bcl-2 and Bcl-xL. The gene discussed is BCL2L1; the disease is central nervous system cancer.