Jo GH et al. demonstrated that irradiating (10 Gy) glioma cell lines at days 3 and 5 induced autophagy followed by apoptosis, and an atg5 knockdown in U373 and LN229 glioma cells after irradiation significantly diminished both autophagy and apoptosis disregarding caspase activation, indicating that atg5 is required to induce apoptosis [16]. Here, ATG5 is linked to central nervous system cancer.