Due to its complex etiology, the pathogenesis of AD has not been completely elucidated, and multiple factors are thought to contribute to the development of AD, including deficits of acetylcholine (ACh), amyloid-β (Aβ) deposits, hyperphosphorylated tau protein, oxidative stress, dyshomeostasis of biometals and neuroinflammation [7,8,9,10,11]. Here, MAPT is linked to Alzheimer disease.