Although the reported genetic risk factors for AD vary among studies depending on sample size, location of collection, and methods for data analysis, data from recent studies involving thousands of patients have identified associations for APOE, CLU, CR1, BIN1, PICALM, CD33, ABCA7, CD2AP, EPHA1, MS4, and TREM2 [42,49,50,51]. The gene discussed is APOE; the disease is Alzheimer disease.