The YAP-p73 complex results in transcription of the pro-apoptotic target gene PUMA in breast cancer cells [8] and Ankyrin Repeat Domain 1 (ANKRD1), which is in some circumstances considered to be a tumor suppressor gene, because it is epigenetically inactivated in human cancer and reduces colony formation of cancer cells [87]. The gene discussed is ANKRD1; the disease is breast carcinoma.