It was suggested that F-box and WD repeat domain-containing 7 (Fbxw7), a well-known F-box protein in the SCF (SKP1-CUL1-F-box protein) E3 ligase complex [106], can directly bind to YAP and decreases the accumulation of YAP in hepatocellular carcinoma cells [107]. Here, FBXW7 is linked to hepatocellular carcinoma.