CCS and Hypertension: The role of calcium channels (CCs) in hypertension is also widely recognized, and the ‘2013 Guidelines for the Management of Arterial Hypertension’ [4], published by the European Society of Hypertension (ESH) together with the European Society of Cardiology (ESC), recommended calcium channel blockers (CCBs) as the initial therapy, alone or in combination with other drug classes.