2′-O-ribose methylation was enhanced by either functional loss of p53 or via the activation of Myc, resulting in the increased activity of rRNA 2′ O methyltransferase fibrillarin and subsequent increase in the IRES-mediated translation of oncogenic mRNAs in addition to causing translation infidelity leading to tumor progression [12,87,88,89,90,91]. This evidence concerns the gene MYC and neoplasm.