TARDBP and amyotrophic lateral sclerosis: In the case of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), aggregates of two RNA-binding proteins (RBPs), the TAR DNA-binding protein of 43 kDa (TDP-43) and the fused in sarcoma (FUS) gene product, are found in the cytoplasm of affected neurons [1,2].