RanGAP1 forms accumulations that co-localize with cytoplasmic RNA foci in C9orf72 ALS (C9-ALS) postmortem brain tissue, in iPSN cells derived from C9-ALS patients, and in Drosophila cells expressing such G4C2 repeats [20]. This evidence concerns the gene RANGAP1 and amyotrophic lateral sclerosis.