TAC1 and neoplasm: Figure 11C illustrated that TCA1 directly associate with TACR1, TACR2 and TACR3. As mentioned previously, TAR3 was overexpressed in EC tissues (Figure 5A). So, we hypothesized that LOC134466/hsa-miR-196a-5p/TAC1 axis performed tumor suppressive function through activating neuroactive ligand-receptor interaction (Figure 10D).