INS and Insulin resistance: 2014). In fact, a daily oral dose of 500 mg of fucoidan to overweight/obese humans for 3 months increased both insulin levels and a marker of insulin resistance (HOMA‐IR). This fucoidan‐mediated deterioration of insulin resistance in obese humans occurred despite a reduction in blood pressure and lowering of LDL cholesterol (Hernández‐Corona et al. 2014).