To identify the downstream targets that are potentially regulated by FOXM1c and simultaneously contribute to oesophageal cancer metastasis, we next tested 15 previously reported genes that are regulated by FOXM1 and highly associated with cancer metastasis (Figure S4).23, 36, 37, 38, 39, 40 To identify which gene is responsible for FOXM1c regulation of ESCC cell metastasis, we assessed the alterations of mRNA levels of 15 genes by RT‐PCR after knocking down FOXM1c expression with specific siRNA. The gene discussed is FOXM1; the disease is cancer.