AKT1 and hepatocellular carcinoma: In ovarian cancer cell lines, CSE1L regulates the expression of the pro‐apoptotic genes RASSF1C and RASSF1A to protect tumour cells from death.26 Another study suggested that AKT activation forces the nuclear accumulation of CSE1L in the ovarian cancer cell, likely to induce pro‐oncogenic signals.17 Winkler et al27 demonstrated that CSE1L and its transport substrate importin‐α1 (imp‐α1) are highly expressed in HCC and maintain HCC cell survival by regulating the X‐linked inhibitor of apoptosis.