Sp1 is an ubiquitously expressed transcription factor and is considered to be a general transcription factor required for transcription of a large number of housekeeping genes.40, 62 However, accumulating evidence indicates that Sp1 is upregulated in various types of human cancer, including lung cancer.63 Consistent with these reports, our study also revealed that Sp1 was increased in lung cancer tissues compared with that in adjacent normal tissues. Here, SP1 is linked to cancer.