KLF3 was originally discovered as a CACCC box‐binding transcription factor in erythroid cells.48 In fact, similar to other KLF members, KLF3 exhibits both transcriptional activation and repression via interaction with other factors.27, 49 Although the role of KLF3 has been extensively studied in the development of hematopoietic system, little is known about KLF3 in cancer. Here, KLF3 is linked to cancer.