Evaluating the simultaneous presence of the deletion in both FCGR3B and ADAM3A loci, we observed that their joint presence contributes to the increase of susceptibility to SLE (p = 1.4 x 10−4, OR = 5.9 [95% CI, 2.5–15.9]) when compared to a deletion only in the FCGR3B gene. Here, FCGR3B is linked to systemic lupus erythematosus.