CFHR5 and systemic lupus erythematosus: The involvement of CFHR5 in renal diseases, e.g. CFHR5 nephropathy [36], has particular interest in view of the SLE patient who present the rare deletion in CFHR5 here identified has lupus nephritis, suggesting that losses in this gene may compromise renal functioning and indicating that this variation may be related to lupus nephritis development.