With SKMEL-2 other highly over-expressed identifications were uniquely found, namely: CDHR2, a tumor suppressor; PECAM1, involved in leukocyte migration, angiogenesis and integrin activation; GPER1 (G-protein coupled receptor 1); S100A1, a tumor suppressor; SLC30A3, involved in transmembrane transported activity. The gene discussed is CMKLR2; the disease is neoplasm.