Instead, fifteen DEGs were exclusively found in SKMEL-2, examples being SIRT7, PCSK4, H1F0, BCL6, SAP30, HIST1H3D, TLE4 etc. In particular, SIRT7 is involved in aging, cancer and circadian rhythm, while BCL6 is a transcriptional repressor involved in the immune system. The gene discussed is SIRT7; the disease is cancer.