Using the 13 available baseline variables, including age, EF, NYHA class, serum Cr, diabetes, systolic BP, BMI, HF duration, current smoker, COPD, male gender, evidence-based medication beta blocker, and ACE inhibitor or ARBs, can construct the risk score and identify the risks of hospitalized patients easily at low cost. The gene discussed is ACE; the disease is chronic obstructive pulmonary disease.