SPINT2 and acute myeloid leukemia: To better understand the role of SPINT2/HAI‐2 down‐regulation in MDS‐BMMSC and de novo AML‐BMMSC physiology, we investigated the role of SPINT2 inhibition by transducing human HS‐5 stromal cells with lentivirus‐mediated shRNA targeting SPINT2 or an appropriate control.