The alpha integrins are known to play an important role in the interaction between hematopoietic stem cell and bone marrow microenvironment niche, controlling hematopoiesis.29 In this sense, we analysed the expression of the alpha integrin family (CD49b [α2], CD49d [α4] and CD49e [α5]) in BMMSC from healthy donors, myelodysplastic syndrome patients, and AML patients. Here, ITGA4 is linked to acute myeloid leukemia.