Thus, in this study, we investigate whether this loss of expression was due to SPINT2/HAI‐2 methylation in order to better understand the role of SPINT2/HAI‐2 down‐regulation in MDS and de novo AML physiopathology and its contribution to leukaemic bone marrow microenvironment. The gene discussed is SPINT2; the disease is acute myeloid leukemia.