As we previously observed a significantly decreased expression of SPINT2 mRNA in MDS‐BMMSC compared to HD‐BMMSC,14 we evaluated SPINT2 mRNA and HAI‐2 expression in 1 HD‐BMMSC, 1 MDS‐BMMSC (1 low‐risk MDS‐BMMSC and 1 high‐risk MDS‐BMMSC), and 1 de novo AML‐BMMSC, representative sample from each group, after treatment with a demethylating agent, AZA. Here, SPINT2 is linked to myelodysplastic syndrome.