The increased CD34+ cell adhesion to MSC after SPINT2/HAI‐2 knockdown, prompted us to evaluate the expression of alpha integrins, CD49b (α2), CD49d (α4), and CD49e (α5), in BMMSC from 10 MDS patients, six de novo AML patients, and three healthy donors, as these molecules are known to mediate cell adhesion via HGF. This evidence concerns the gene SPINT2 and acute myeloid leukemia.