Low levels of SPINT2/HAI‐2, probably due to hypermethylation, have been highlighted in various solid cancer types and have been associated with disease progression.7, 8, 9, 10, 11, 12, 13 Pereira and colleagues hypothesized that SPINT2/HAI‐2 is involved in prostate cancer tumourigenesis probably by regulation of SPINT2/HAI‐2.7 We previously reported that the expression of SPINT2 mRNA is significantly lower in bone marrow mesenchymal stromal cell (BMMSC) from MDS patients compared to healthy donors (HD), which could be related with increased HGF and CXCL‐12 secretion.14 Here, SPINT2 is linked to Familial prostate cancer.