ITGA5 and acute myeloid leukemia: Moreover, CD49e participates in the activation of some kinases that regulate cell growth, survival, differentiation, and/or migration.31 Thus, CD49d probably helps to the maintain CD34+ cells in contact with BMMSC in MDS‐BMMSC and de novo AML‐BMMSC, and CD49e probably activates some kinase signalling pathway in leukaemic cells that increase cell survival and proliferation.