Moreover, CD49e participates in the activation of some kinases that regulate cell growth, survival, differentiation, and/or migration.31 Thus, CD49d probably helps to the maintain CD34+ cells in contact with BMMSC in MDS‐BMMSC and de novo AML‐BMMSC, and CD49e probably activates some kinase signalling pathway in leukaemic cells that increase cell survival and proliferation. This evidence concerns the gene ITGA4 and acute myeloid leukemia.