These results indicate that SPINT2/HAI‐2 is probably epigenetically silenced by methylation in these haematological neoplasms, maybe acting as a tumour suppressor gene in MDS and de novo AML, as occurs in some solid tumours, such as prostate cancer, melanoma, hepatocellular carcinoma, esophageal squamous cell carcinoma, endometrial/uterine cancer, gastric cancer, and medulloblastoma.7, 8, 9, 10, 11, 12, 13, 18, 23. This evidence concerns the gene SPINT2 and esophageal squamous cell carcinoma.