SPINT2 and myelodysplastic syndrome: This gene encodes a HAI‐2 protein, an endogenous inhibitor of the HGF activator (HFGA), which is responsible for the activation of HGF, a polypeptide secreted by MSC that acts as a multifunctional cytokine, regulating cell adhesion, cell growth, and cell survival of hematopoietic cells through MET pathways.18 In MDS and de novo AML patients, the levels of HGF cytokine in the serum are significantly increased and represent a predictor of survival.5, 6 Kentsis and colleagues showed that up‐regulation of HGF expression was responsible for the maintenance of leukemogenic signalling.19