Hence, the down‐regulation in SPINT2/HAI‐2 expression profile, probably due to promoter methylation, in MDS and de novo AML BMMSCs, provides novel insights of SPINT2/HAI‐2 into the pathogenic role of the dysplastic and leukaemic bone marrow microenvironment. This evidence concerns the gene SPINT2 and acute myeloid leukemia.